Open AccessMyocardial infarction and stem cells
Author(s) -
K Ananda Krishna,
Keshav Krishna,
Ruben Berrocal,
Krithika Rao,
K.R.S. Sambasiva Rao
Publication year - 2011
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.80761
Subject(s) - myocardial infarction , regeneration (biology) , stem cell , medicine , cardiac function curve , cardiology , stem cell therapy , myocyte , heart failure , intensive care medicine , bioinformatics , surgery , microbiology and biotechnology , transplantation , biology
Permanent loss of cardiomyocytes and scar tissue formation after myocardial infarction (MI) results in an irreversible damage to the cardiac function. Cardiac repair (replacement, restoration, and regeneration) is, therefore, essential to restore function of the heart following MI. Existing therapies lower early mortality rates, prevent additional damage to the heart muscle, and reduce the risk of further heart attacks. However, there is need for treatment to improve the infarcted area by replacing the damaged cells after MI. Thus, the cardiac tissue regeneration with the application of stem cells may be an effective therapeutic option. Recently, interest is more inclined toward myocardial regeneration with the application of stem cells. However, the potential benefits and the ability to improve cardiac function with the stem cell-based therapy need to be further addressed. In this review, we focus on the clinical applications of stem cells in the cardiac repair.