Open AccessDifferential scanning calorimetry: An invaluable tool for a detailed thermodynamic characterization of macromolecules and their interactions
Author(s) -
Michael H. Chiu,
Elmar J. Prenner
Publication year - 2011
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.76463
Subject(s) - differential scanning calorimetry , thermotropic crystal , drug delivery , macromolecule , excipient , characterization (materials science) , chemistry , drug , liposome , nanotechnology , materials science , phase (matter) , chromatography , pharmacology , organic chemistry , biochemistry , medicine , thermodynamics , physics , liquid crystalline
Differential Scanning Calorimetry (DSC) is a highly sensitive technique to study the thermotropic properties of many different biological macromolecules and extracts. Since its early development, DSC has been applied to the pharmaceutical field with excipient studies and DNA drugs. In recent times, more attention has been applied to lipid-based drug delivery systems and drug interactions with biomimetic membranes. Highly reproducible phase transitions have been used to determine values, such as, the type of binding interaction, purity, stability, and release from a drug delivery mechanism. This review focuses on the use of DSC for biochemical and pharmaceutical applications.