Open AccessFast dissolving strips: A novel approach for the delivery of verapamil
Author(s) -
S Kunte,
Prasad Tandale
Publication year - 2010
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.72133
Subject(s) - dissolution , verapamil , aspartame , maltodextrin , bioavailability , materials science , pharmacology , chromatography , chemistry , medicine , calcium , spray drying , organic chemistry , metallurgy , biochemistry
Fast dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablets/capsules etc. Verapamil is a calcium channel blocker used as an antianginal, antiarrhythmic, and antihypertensive agent with extensive first pass metabolism which results in less bioavailability. This work investigated the possibility of developing verapamil fast dissolving strips allowing fast, reproducible drug dissolution in the oral cavity; thus bypassing first pass metabolism.