Open AccessQSAR studies of benzofuran/benzothiophene biphenyl derivatives as inhibitors of PTPase-1B
Author(s) -
Darpan Kaushik,
Rajnish Kumar,
Abhishek Saxena
Publication year - 2010
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.62703
Subject(s) - quantitative structure–activity relationship , benzofuran , chemistry , insulin receptor , stereochemistry , biochemistry , biology , insulin , insulin resistance , endocrinology
Insulin resistance is associated with a defect in protein tyrosine phosphorylation in the insulin signal transduction cascade. The PTPase enzyme dephosphorylates the active form of the insulin receptor and thus attenuates its tyrosine kinase activity, therefore, the need for a potent PTPase inhibitor exists, with the intention of which the QSAR was performed.