Open AccessDevelopment and validation of stability indicating method for the quantitative determination of venlafaxine hydrochloride in extended release formulation using high performance liquid chromatography
Author(s) -
Jaspreet Kaur,
S. Kalyanasundaram,
Alex Joseph,
Abhishek Gupta,
Yogendra Singh,
Kona S Srinivas,
G. Vinay Jain
Publication year - 2010
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.62701
Subject(s) - venlafaxine , chromatography , venlafaxine hydrochloride , chemistry , high performance liquid chromatography , detection limit , antidepressant , medicine , hippocampus
Venlafaxine,hydrochloride is a structurally novel phenethyl bicyclic antidepressant, and is usually categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI) but it has been referred to as a serotonin-norepinephrine-dopamine reuptake inhibitor. It inhibits the reuptake of dopamine. Venlafaxine HCL is widely prescribed in the form of sustained release formulations. In the current article we are reporting the development and validation of a fast and simple stability indicating, isocratic high performance liquid chromatographic (HPLC) method for the determination of venlafaxine hydrochloride in sustained release formulations.