Open AccessThymol, a monoterpene, inhibits aldose reductase and high-glucose-induced cataract on isolated goat lens
Author(s) -
Divya M. Kanchan,
Smita S. Kale,
Gauresh Somani,
Aakruti Kaikini,
Sadhana Sathaye
Publication year - 2016
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.199348
Subject(s) - thymol , aldose reductase , antioxidant , chemistry , enzyme , quercetin , ic50 , biochemistry , pharmacology , cuminum , monoterpene , in vitro , food science , medicine , essential oil
Overactivation of aldose reductase (AR) enzyme has been implicated in the development of various diabetic complications. In the present study, the inhibitory effect of thymol was investigated on AR enzyme and its anti-cataract activity was also examined on isolated goat lens.