Open AccessTherapeutic potential of alpha-ketoglutarate against acetaminophen-induced hepatotoxicity in rats
Author(s) -
Lalita Mehra,
Yasha Hasija,
Gaurav Mittal
Publication year - 2016
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.199345
Subject(s) - malondialdehyde , acetaminophen , oxidative stress , superoxide dismutase , glutathione , pharmacology , alkaline phosphatase , chemistry , catalase , biochemistry , medicine , enzyme
Alpha-ketoglutarate (α-KG) is a cellular intermediary metabolite of Krebs cycle, involved in energy metabolism, amino acid synthesis, and nitrogen transport. It is available over-the-counter and marketed as a nutritional supplement. There is a growing body of evidence to suggest that dietary α-KG has the potential to maintain cellular redox status and thus can protect various oxidative stress induced disease states. The aim of the present study was to investigate the hepatoprotective role of α-KG in acetaminophen (APAP) induced toxicity in rats.