Open AccessIn vitro screening on amyloid beta modulation of aqueous extracts from plant seeds
Author(s) -
Yoshinori Okada,
Mizue Okada
Publication year - 2016
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.171688
Subject(s) - glycation , chemistry , bovine serum albumin , amyloid (mycology) , oxidative stress , biochemistry , polyphenol , food science , antioxidant , inorganic chemistry , receptor
Glycation process might contribute to both extensive protein cross-linking and oxidative stress in Alzheimer's disease (AD). The amyloid-like aggregation of glycated bovine serum albumin induces apoptosis in the neuronal cell. Dietary supplementation of antioxidants, vitamins, and polyphenols are beneficial to AD, and consumption of fruits and vegetables reduce the risk of AD. We conducted a screening of 14 aqueous extracts from plant seeds (PSAE) for inhibitory activity on amyloid beta (Aβ).