Open AccessCharacterization of pioglitazone cyclodextrin complexes: Molecular modeling to in vivo evaluation
Author(s) -
D. M. Bramhane,
Preethi A Kulkarni,
Elvis A. F. Martis,
Raghuvir R. S. Pissurlenkar,
Evans C. Coutinho,
Mangal S. Nagarsenker
Publication year - 2016
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.171680
Subject(s) - solubility , chemistry , differential scanning calorimetry , aqueous solution , cyclodextrin , dissolution , pioglitazone , in vivo , nuclear chemistry , fourier transform infrared spectroscopy , chromatography , chemical engineering , thermodynamics , medicine , physics , microbiology and biotechnology , biology , type 2 diabetes , engineering , diabetes mellitus , endocrinology
The objective of present study was to study the influence of different β-cyclodextrin derivatives and different methods of complexation on aqueous solubility and consequent translation in in vivo performance of Pioglitazone (PE).