Synthesis, characterization and in silico biological activity of some 2-(N,N-dimethyl guanidinyl)-4,6-diaryl pyrimidines | Zendy

Rajasekhar Komarla Kumarachari | Zendy; Sivakumar Peta | Zendy; Abdrrahman Shemsu Surur | Zendy; YenusTadesse Mekonnen | Zendy

Open Access

Synthesis, characterization and in silico biological activity of some 2-(N,N-dimethyl guanidinyl)-4,6-diaryl pyrimidines

Author(s) -

Rajasekhar Komarla Kumarachari,

Sivakumar Peta,

Abdrrahman Shemsu Surur,

YenusTadesse Mekonnen

Publication year - 2015

Publication title -

journal of pharmacy and bioallied sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.268

H-Index - 36

eISSN - 0976-4879

pISSN - 0975-7406

DOI - 10.4103/0975-7406.171678

Subject(s) - pyrimidine , chemistry , lipinski's rule of five , biological activity , ring (chemistry) , stereochemistry , antimicrobial , benzene , quantitative structure–activity relationship , combinatorial chemistry , in silico , organic chemistry , biochemistry , in vitro , gene

As pyrimidine is a basic nucleus in DNA and RNA, it has been found to be associated with diverse biological activities. Pyrimidine derivatives were reported to possess anticonvulsant, antimicrobial, anti-inflammatory, antitumor, and antihistaminic. Recently, our team reported the anti-inflammatory and antimicrobial evaluation of some pyrimidines.

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