Open AccessA high performance thin layer chromatographic method for the estimation of colchicine in different formulations
Author(s) -
Mohammad Fahim,
Mhaveer Singh,
YT Kamal,
Hayat M. Mukhtar,
Sayeed Ahmad
Publication year - 2015
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.168021
Subject(s) - chromatography , colchicine , detection limit , high performance thin layer chromatography , silica gel , chemistry , thin layer chromatography , medicine
Colchicine is a main alkaloid present in bitter and sweet variety of colchicum (Colchicum luteum Baker), which have been reported to possess anti-rheumatic, anti-gout, and anticancer potential. Colchicum is an important ingredient of several Unani and Herbal formulations. Quantification of colchicine will play a great role in quality control of these formulations. Hence, a high-performance thin layer chromatographic (TLC) method has been developed for the analysis of colchicine in Unani formulations of various dosage forms such as hubb (tablet) and capsules.