Open AccessMultiple myeloma involving mandible: In an elderly female
Author(s) -
C Sreeja,
B Vijayabanu,
D Vijayalakshmi,
M. Uma Devi,
Karthik Ramakrishnan,
K Dhivya
Publication year - 2015
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.163551
Subject(s) - multiple myeloma , medicine , plasma cell , plasmacytoma , plasma cell neoplasm , pathology , skull , malignancy , histopathology , bone marrow , mandible (arthropod mouthpart) , immunoglobulin light chain , hematologic malignancy , anemia , antibody , biology , anatomy , immunology , botany , genus
Multiple myeloma (MM) is a malignancy of plasma cell origin. It often has a multicentric origin within the bone. It makes about 1% of all malignancies and 15% of all hematologic malignancies. There is a monoclonal proliferation of abnormal plasma cells in this disease that arise from a single malignant precursor that has undergone uncontrolled mitotic division. These cells in turn produce one type of immunoglobulin light chain, either kappa or lambda. Unifocal, monoclonal proliferation of plasma cells is called plasmacytoma. Hereby, we present a case of a 65-year-old female patient who presented with a swelling of the mandible. The uniform sheets of plasma cells in the histopathology punched out radiolucencies in skull radiograph and the blood picture of anemia and hypercalcemia, confirmed the case as MM.