Stevens-Johnson syndrome induced by a combination of lamotrigine and valproic acid | Zendy

S. Kavitha | Zendy; T Anbuchelvan | Zendy; V Mahalakshmi | Zendy; R Sathya | Zendy; T R Sabarinath | Zendy; N Gururaj | Zendy; S Kalaivani | Zendy

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Stevens-Johnson syndrome induced by a combination of lamotrigine and valproic acid

Author(s) -

S. Kavitha,

T Anbuchelvan,

V Mahalakshmi,

R Sathya,

T R Sabarinath,

N Gururaj,

S Kalaivani

Publication year - 2015

Publication title -

journal of pharmacy and bioallied sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.268

H-Index - 36

eISSN - 0976-4879

pISSN - 0975-7406

DOI - 10.4103/0975-7406.163545

Subject(s) - lamotrigine , valproic acid , toxic epidermal necrolysis , medicine , pharmacovigilance , dermatology , regimen , pharmacology , epilepsy , drug , psychiatry

Lamotrigine and valproic acid are well-tolerated anticonvulsants, but frequently associated with severe cutaneous reactions, such as the Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis, when used in combination. We report a case of SJS likely induced by the use of a lamotrigine and valproic acid regimen and as a dental surgeon it is important to identify such lesion and report to pharmacovigilance.

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