Open AccessStevens-Johnson syndrome induced by a combination of lamotrigine and valproic acid
Author(s) -
S. Kavitha,
T Anbuchelvan,
V Mahalakshmi,
R Sathya,
TR Sabarinath,
N Gururaj,
S Kalaivani
Publication year - 2015
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.163545
Subject(s) - lamotrigine , valproic acid , toxic epidermal necrolysis , medicine , pharmacovigilance , dermatology , pharmacology , epilepsy , drug , psychiatry
Lamotrigine and valproic acid are well-tolerated anticonvulsants, but frequently associated with severe cutaneous reactions, such as the Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis, when used in combination. We report a case of SJS likely induced by the use of a lamotrigine and valproic acid regimen and as a dental surgeon it is important to identify such lesion and report to pharmacovigilance.