Open AccessEnzymatic antioxidants and its role in oral diseases
Author(s) -
J Sathiya Jeeva,
J Sunitha,
R Ananthalakshmi,
S Rajkumari,
Maya Ramesh,
Krishnan Ravindran
Publication year - 2015
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.163438
Subject(s) - radical , catalase , superoxide dismutase , antioxidant , enzyme , chemistry , biochemistry , glutathione peroxidase , detoxification (alternative medicine) , peroxidase , free radical theory of aging , glutathione , medicine , pathology , alternative medicine
Antioxidants are substances that when present at very low concentration inhibits the oxidation of a molecule. It has the capacity to nullify the ill effects of oxidation caused by free radicals in the living organisms. The unpaired electrons of these free radicals are highly reactive and neutralize the harmful reactions of human metabolism. Protection of the body against free radicals is provided by some enzymes which come under a distinctive group, concerned solely with the detoxification of these radicals. Superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase are the key enzymatic antioxidants of this defense system by which the free radicals that are produced during metabolic reactions are removed. This review highlights the mechanism of action of enzymatic antioxidants SOD, GPX and catalase and its role in oral disease.