Open AccessIn-silico gene co-expression network analysis in Paracoccidioides brasiliensis with reference to haloacid dehalogenase superfamily hydrolase gene
Author(s) -
Raghunath Satpathy,
V. Badireenath Konkimalla,
Jagnyeswar Ratha
Publication year - 2015
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.160023
Subject(s) - paracoccidioides brasiliensis , dehalogenase , gene , in silico , biology , gene annotation , computational biology , gene expression profiling , gene co expression network , dna microarray , genetics , gene expression , genome , microbiology and biotechnology , gene ontology
Paracoccidioides brasiliensis, a dimorphic fungus is the causative agent of paracoccidioidomycosis, a disease globally affecting millions of people. The haloacid dehalogenase (HAD) superfamily hydrolases enzyme in the fungi, in particular, is known to be responsible in the pathogenesis by adhering to the tissue. Hence, identification of novel drug targets is essential.