Open AccessDNA adducts-chemical addons
Author(s) -
T. R. Rajalakshmi,
N Aravindhababu,
K. T. Shanmugam,
K. M. K. Masthan
Publication year - 2015
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.155901
Subject(s) - dna , adduct , chemistry , chemical genetics , dna replication , covalent bond , genetics , biochemistry , microbiology and biotechnology , biology , computational biology , organic chemistry , small molecule
DNA adduct is a piece of DNA covalently bond to a chemical (safrole, benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. When a chemical binds to DNA, it gets damaged resulting in abnormal replication. This could be the start of a mutation and without proper DNA repair, this can lead to cancer. It is this chemical that binds with the DNA is our prime area of concern. Instead of performing the whole body analysis for diagnosing cancer, this test could be carried out for early detection of cancer. When scanning tunneling microscope is used, the DNA results can be obtained earlier. DNA adducts in scientific experiments are used as biomarkers.