Antioxidant activity of ethanolic extract of Tinospora cordifolia on N-nitrosodiethylamine (diethylnitrosamine) induced liver cancer in male Wister albino rats | Zendy

V Ramesh | Zendy; Ramachandran Jayaprakash | Zendy; MP Sridhar | Zendy; C Sasikala | Zendy

Open Access

Antioxidant activity of ethanolic extract of Tinospora cordifolia on N-nitrosodiethylamine (diethylnitrosamine) induced liver cancer in male Wister albino rats

Author(s) -

V Ramesh,

Ramachandran Jayaprakash,

MP Sridhar,

C Sasikala

Publication year - 2015

Publication title -

journal of pharmacy and bioallied sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.268

H-Index - 36

eISSN - 0976-4879

pISSN - 0975-7406

DOI - 10.4103/0975-7406.155791

Subject(s) - tinospora cordifolia , antioxidant , lipid peroxidation , carcinogen , chemistry , pharmacology , oxidative stress , liver cancer , traditional medicine , cancer , biochemistry , medicine

Cancer is a disease that evokes wide spread fear among people and is one of the leading causes of deaths in the world. Diethylnitrosamine (DEN) is a known carcinogen in rodent liver. DENs reported to undergo metabolic activation by cytochrome P450 enzymes to form reactive electrophiles that cause oxidative stress leading to cytotoxicity, mutagenicity and carcinogenicity.

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