Open AccessAntioxidant activity of ethanolic extract of Tinospora cordifolia on N-nitrosodiethylamine (diethylnitrosamine) induced liver cancer in male Wister albino rats
Author(s) -
Ramachandran Jayaprakash,
V. Ramesh,
M. Sridhar,
C Sasikala
Publication year - 2015
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.155791
Subject(s) - tinospora cordifolia , antioxidant , lipid peroxidation , carcinogen , chemistry , pharmacology , oxidative stress , liver cancer , traditional medicine , cancer , biochemistry , medicine
Cancer is a disease that evokes wide spread fear among people and is one of the leading causes of deaths in the world. Diethylnitrosamine (DEN) is a known carcinogen in rodent liver. DENs reported to undergo metabolic activation by cytochrome P450 enzymes to form reactive electrophiles that cause oxidative stress leading to cytotoxicity, mutagenicity and carcinogenicity.