Open AccessIn vitro acetylcholinesterase inhibition by psoralen using molecular docking and enzymatic studies
Author(s) -
Gauresh Somani,
Chinmay Kulkarni,
Prashant Shinde,
Rupesh U. Shelke,
K. S. Laddha,
Sadhana Sathaye
Publication year - 2015
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.148775
Subject(s) - psoralen , acetylcholinesterase , chemistry , enzyme , docking (animal) , psoralea corylifolia , biochemistry , aché , acetylcholine , in vitro , enzyme assay , pharmacology , biology , medicine , dna , alternative medicine , nursing , pathology
Alzheimer's disease (AD) has increased at an alarming rate and is now a worldwide health problem. Inhibitors of acetylcholinesterase (AChE) leading to inhibition of acetylcholine breakdown constitute the main therapeutic strategy for AD. Psoralen was investigated as inhibitor of AChE enzyme in an attempt to explore its potential for the management of AD.