Open AccessGellan gum-based mucoadhesive microspheres of almotriptan for nasal administration: Formulation optimization using factorial design, characterization, and in vitro evaluation
Author(s) -
Zaheer Abbas,
Sachin Marihal
Publication year - 2014
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.142959
Subject(s) - mucoadhesion , factorial experiment , gellan gum , nasal administration , zeta potential , chromatography , materials science , differential scanning calorimetry , particle size , biomedical engineering , pharmacology , chemistry , drug delivery , medicine , drug carrier , nanotechnology , mathematics , food science , statistics , physics , nanoparticle , thermodynamics
Almotriptan malate (ALM), indicated for the treatment of migraine in adults is not a drug candidate feasible to be administered through the oral route during the attack due to its associated symptoms such as nausea and vomiting. This obviates an alternative dosage form and nasal drug delivery is a good substitute to oral and parenteral administration.