Open AccessImmunohistochemical study of p53 and proliferating cell nuclear antigen expression in odontogenic keratocyst and periapical cyst
Author(s) -
Thara Purath Sajeevan,
Tillai Rajasekaran Saraswathi,
Kannan Ranganathan,
Elizabeth Joshua,
Umadevi K Rao
Publication year - 2014
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.137388
Subject(s) - proliferating cell nuclear antigen , keratocyst , immunohistochemistry , pathology , staining , h&e stain , biology , medicine , cyst
p53 protein is a product of p53 gene, which is now classified as a tumor suppressor gene. The gene is a frequent target for mutation, being seen as a common step in the pathogenesis of many human cancers. Proliferating cell nuclear antigen (PCNA) is an auxiliary protein of DNA polymerase delta and plays a critical role in initiation of cell proliferation.