Open AccessGranularity in granular cell ameloblastoma
Author(s) -
Andamuthu Yamunadevi,
GS Madhushankari,
M Selvamani,
Praveen S Basandi,
Thukanayyakanpalayam Ragunathan Yoithapprabhunath,
N. Ganapathy
Publication year - 2014
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.137253
Subject(s) - granularity , granular cell , ameloblastoma , pathological , pathology , immunohistochemistry , cell , differential diagnosis , biology , medicine , computer science , neuroscience , anatomy , genetics , maxilla , operating system , central nervous system
Granular cell ameloblastoma (GCA) is one of the rare histological variants of ameloblastoma (1.5-3.5%), identified by Krompechner in 1918 and is diagnosed by the characteristic presence of granular cells. These granular cells are seen in several physiological and pathological conditions and the granularity in GCA is due to lysosomal aggregates. This review is about the clinical features, histopathological features and differential diagnosis of GCA and also adds the theories for occurrence of granularity, electron microscopic findings, cell signaling pathways and immunohistochemistry findings related to these granular cells in GCA.