Open AccessFormulation and evaluation of sustained release matrix tablet of rabeprazole using wet granulation technique
Author(s) -
Ruqaiyah Khan,
Shamim Ashraf,
Muhammad Afzal,
Imran Kazmi,
Mohammed Asadullah Jahangir,
Rajbala Singh,
Ramesh Chandra,
Firoz Anwar
Publication year - 2014
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.130961
Subject(s) - bioavailability , rabeprazole , granulation , friability , pharmacology , chemistry , matrix (chemical analysis) , chromatography , medicine , materials science , first pass effect , omeprazole , composite material
Rabeprazole, a member of substituted benzimidazoles, inhibits the final step in gastric acid secretions. This drug claims to cause fastest acid separation (due to higher pKa), and more rapidly converts to the active species to aid gastric mucin synthesis. The most significant pharmacological action of Rabeprazole is dose dependent suppression of gastric acid secretion; without anticholinergic or H2-blocking action. It completely abolishes the hydrochloric acid secretion as it is powerful inhibitor of gastric acid. Rabeprazole is acid labile and hence commonly formulated as an enteric coated tablet. The absorption of rabeprazole occurs rapidly as soon as tablet leaves the stomach.