Open AccessReduction in mortality and teratogenicity following simultaneous administration of folic acid and vitamin E with antiepileptic, antihypertensive and anti-allergic drugs
Author(s) -
Shahana Wahid,
Rafeeq Alam Khan,
Zeeshan Feroz
Publication year - 2014
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.130955
Subject(s) - medicine , levetiracetam , loratadine , pharmacology , folic acid , lamotrigine , vitamin , epilepsy , teratology , drug , pregnancy , biology , gestation , psychiatry , genetics
The present study was designed to evaluate the teratogenic effects on breeding pattern in mice following administration of lamotrigine (LT) and levetiracetam (LV) and its combination with anti-hypertensive and anti-allergic drugs. Moreover, possibility of decrease in teratogenic effect was also evaluated upon simultaneous administration of these combinations with folic acid or vitamin E.