Open AccessThermal latency studies in opiate-treated mice
Author(s) -
Noam Schildhaus,
Eliana Trink,
Chirs Polson,
Louis J. DeTolla,
Betty Tyler,
George I. Jallo,
Sino Tok,
Michael Guarnieri
Publication year - 2014
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.124316
Subject(s) - buprenorphine , tail flick test , opiate , stimulation , medicine , anesthesia , nociception , pharmacology , morphine , opioid , receptor
The change in the reaction time of a tail or paw exposed to a thermal stimulus is a measure of nociceptive activity in laboratory animals. Tail-flick and plantar thermal sensitivity (Hargreaves) tests are non-invasive, minimize stress, and can be used to screen animals for phenotype and drug activity.