Open AccessSubcutaneous implants for long-acting drug therapy in laboratory animals may generate unintended drug reservoirs
Author(s) -
Michael Guarnieri,
Betty Tyler,
Louis J. DeTolla,
Ming Zhao,
Barry J. Kobrin
Publication year - 2014
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.124315
Subject(s) - drug , implant , medicine , bioavailability , pharmacology , drug delivery , pharmacokinetics , surgery , chemistry , organic chemistry
Long-acting therapy in laboratory animals offers advantages over the current practice of 2-3 daily drug injections. Yet little is known about the disintegration of biodegradable drug implants in rodents.