Open AccessA cyclodextrin formulation to improve use of the anesthetic tribromoethanol (Avertin ® )
Author(s) -
Arlene McDowell,
Jessica A Fothergill,
Azeem Khan,
Natalie J. Medlicott
Publication year - 2014
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.124303
Subject(s) - anesthetic , cyclodextrin , solubility , pharmacodynamics , chemistry , anesthesia , dose , pharmacology , drug , chromatography , pharmacokinetics , medicine , organic chemistry
Efficacy and safety concerns have been raised in the literature with the use of tribromoethanol (TBE) (Avertin(®)) for anesthesia in rats and mice when administered by intraperitoneal (IP) injection. Despite the controversy, it remains in common usage as an anesthetic agent in laboratory rodents for short-term surgical procedures. Cyclodextrins have been shown to improve drug solubility and were investigated here as an improved anesthetic formulation for mice.