Open AccessProtective effects of plant seed extracts against amyloid β-induced neurotoxicity in cultured hippocampal neurons
Author(s) -
Yoshinori Okada,
Mizue Okada
Publication year - 2013
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.111819
Subject(s) - neurotoxicity , hippocampal formation , amyloid β , neuroscience , pharmacology , amyloid (mycology) , chemistry , traditional medicine , biology , medicine , pathology , botany , toxicity , disease
Alzheimer's disease (AD) is characterized by large deposits of amyloid β (Aβ) peptide. Aβ is known to increase reactive oxygen species (ROS) production in neurons, leading to cell death. In this study, we screened 15 plant seeds' aqueous extracts (PSAE) for inhibitory effects on Aβ (25-35)-induced cell death using hippocampus neurons (HIPN).