Open AccessSynthesis and PASS-assisted in silico approach of some novel 2-substituted benzimidazole bearing a pyrimidine-2, 4, 6(trione) system as mucomembranous protector
Author(s) -
Bijo Mathew,
Jerad Suresh,
Socklingam Anbazhagan
Publication year - 2013
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.106563
Subject(s) - benzimidazole , pyrimidine , omeprazole , barbituric acid , acetic acid , proton nmr , chemistry , pyridine , stomach , stereochemistry , pharmacology , medicinal chemistry , biochemistry , organic chemistry , medicine
The present paper demonstrates the utility of PASS computer-aided program and makes a clear comparison of predicted and observed pharmacological properties of some novel 5-[(2E)-1-(1H-benzimidazol-2-yl)-3-substituted phenylprop-2-en-1-ylidene] pyrimidine-2, 4, 6 (1H, 3H, 5H)-triones (5a-f).