Synthesis and PASS-assisted in silico approach of some novel 2-substituted benzimidazole bearing a pyrimidine-2, 4, 6(trione) system as mucomembranous protector | Zendy

Bijo Mathew | Zendy; Jerad Suresh | Zendy; Socklingam Anbazhagan | Zendy

Open Access

Synthesis and PASS-assisted in silico approach of some novel 2-substituted benzimidazole bearing a pyrimidine-2, 4, 6(trione) system as mucomembranous protector

Author(s) -

Bijo Mathew,

Jerad Suresh,

Socklingam Anbazhagan

Publication year - 2013

Publication title -

journal of pharmacy and bioallied sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.268

H-Index - 36

eISSN - 0976-4879

pISSN - 0975-7406

DOI - 10.4103/0975-7406.106563

Subject(s) - benzimidazole , pyrimidine , omeprazole , barbituric acid , acetic acid , proton nmr , chemistry , pyridine , stomach , stereochemistry , pharmacology , medicinal chemistry , biochemistry , organic chemistry , medicine

The present paper demonstrates the utility of PASS computer-aided program and makes a clear comparison of predicted and observed pharmacological properties of some novel 5-[(2E)-1-(1H-benzimidazol-2-yl)-3-substituted phenylprop-2-en-1-ylidene] pyrimidine-2, 4, 6 (1H, 3H, 5H)-triones (5a-f).

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