Open AccessThe application of bone morphogenetic proteins to periodontal and peri-implant tissue regeneration: A literature review
Author(s) -
Karuppanan P Sasikumar,
Sugumari Elavarasu,
Jayaprakash S Gadagi
Publication year - 2012
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.100320
Subject(s) - periodontal fiber , periodontology , bone morphogenetic protein , regeneration (biology) , dentistry , medicine , craniofacial , tissue engineering , bone morphogenetic protein 2 , periodontal ligament stem cells , orthodontics , bioinformatics , biology , biomedical engineering , microbiology and biotechnology , alkaline phosphatase , biochemistry , psychiatry , gene , enzyme , in vitro
Progress in understanding the role of bone morphogenetic proteins (BMPs) in craniofacial and tooth development and the demonstration of stem cells in periodontal ligament have set the stage for periodontal regenerative therapy and tissue engineering. Furthermore, recent approval by the Food and Drug Administration of recombinant human BMPs for accelerating bone fusion in slow-healing fractures indicates that this protein family may prove useful in designing regenerative treatments in periodontics. In the near term, these advances are likely to be applied to periodontal surgery; ultimately, they may facilitate approaches to regenerating whole lost periodontal structures.