Open AccessBisphosphonates: An update
Author(s) -
N. Ganapathy,
Subramanium Gokulnathan,
Nataraj Balan,
Thangadurai Maheswaran,
Venkatesan Venkatesan
Publication year - 2012
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.100309
Subject(s) - medicine , osteoporosis , bone remodeling , bone resorption , pathogenesis , bioinformatics , mechanism (biology) , bisphosphonate , intensive care medicine , dentistry , pathology , biology , philosophy , epistemology
Bisphosphonates are used widely for variety of bone condition, most notably IV bisphosphonates in the treatment of metastic bone lesion and oral bisphosphonates for osteoporosis. They constitute a group of drugs capable of modulating bone turnover and reducing its remodeling when an excessive resorption occurs. In the last few years, due to their extensive use, many cases of complications associated with their use have been published. This paper provides recent knowledge on general characteristics of these drugs and their mechanism of action, pathogenesis, as well as their relevance to dentist.