Open AccessHost modulation by therapeutic agents
Author(s) -
Sugumari Elavarasu,
Santhosh Sekar,
Thamaraiselvan Murugan
Publication year - 2012
Publication title -
journal of pharmacy and bioallied sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 36
eISSN - 0976-4879
pISSN - 0975-7406
DOI - 10.4103/0975-7406.100244
Subject(s) - osteoprotegerin , tumor necrosis factor alpha , medicine , mapk/erk pathway , pharmacology , periodontal fiber , doxycycline , anakinra , interleukin 1 receptor antagonist , kinase , receptor , receptor antagonist , antagonist , chemistry , immunology , disease , biochemistry , dentistry , antibiotics , activator (genetics)
Periodontal disease susceptible group present advanced periodontal breakdown even though they achieve a high standard of oral hygiene. Various destructive enzymes and inflammatory mediators are involved in destruction. These are elevated in case of periodontal destruction. Host modulation aims at bringing these enzymes and mediators to normal level. Doxycycline, nonsteroidal anti-inflammatory drugs (NSAIDs), bisphosphonates, nitrous oxide (NO) synthase inhibitors, recombinant human interleukin-11 (rhIL-11), omega-3 fatty acid, mouse anti-human interleukin-6 receptor antibody (MRA), mitogen-activated protein kinase (MAPK) inhibitors, nuclear factor-kappa B (NF-kb) inhibitors, osteoprotegerin, and tumor necrosis factor antagonist (TNF-α) are some of the therapeutic agents that have host modulation properties.