Open AccessThe 'Milwaukee protocol' (MP) hope does not succeeds for rabies victim
Author(s) -
Anil Agarwal
Publication year - 2017
Publication title -
medical journal of dr. d y patil university/medical journal of dr. d.y. patil university
Language(s) - English
Resource type - Journals
eISSN - 2278-7119
pISSN - 0975-2870
DOI - 10.4103/0975-2870.202098
Subject(s) - rabies , amantadine , rabies virus , virology , virus , transmission (telecommunications) , lyssavirus , medicine , immune system , isolation (microbiology) , ribavirin , biology , immunology , rhabdoviridae , microbiology and biotechnology , computer science , telecommunications , hepatitis c virus
Rabies is caused by the rabies virus, an RNA-based virus in the genus Lyssavirus. Transmission typically occurs when virus-laden saliva from a rabid animal enters a wound or mucous membrane. The Milwaukee protocol, a novel procedure in which the patient was placed in a drug-induced coma and given an antiviral cocktail composed of ketamine, ribavirin, and amantadine. Considering the theory that rabies pathology stems from central nervous system neurotransmitter dysfunction, doctors hypothesized suppressed brain activity would minimize damage while the patient's immune system developed an adequate response