Open AccessNeonatal-onset hemophagocytic lymphohistiocytosis associated with primary dengue infection
Author(s) -
Madhumita Nandi,
Sarbani Misra Roy,
Mrinal Kanti Das,
Chhanda Datta
Publication year - 2016
Publication title -
medical journal of dr. d y patil university/medical journal of dr. d.y. patil university
Language(s) - English
Resource type - Journals
eISSN - 2278-7119
pISSN - 0975-2870
DOI - 10.4103/0975-2870.192154
Subject(s) - hepatosplenomegaly , pancytopenia , hemophagocytic lymphohistiocytosis , dengue fever , medicine , pediatrics , bone marrow , immunology , pathology , disease
A 40-day-old baby presented with prolonged fever, petechial spots, hepatosplenomegaly, generalized lymphadenopathy, and pancytopenia. Investigations revealed positive anti-dengue virus IgM antibody, and bone marrow examination demonstrated the presence of hemophagocytes. The diagnosis of hemophagocytic lymphohistiocytosis (HLH) was made according to HLH-2004 guidelines. HLH associated with primary dengue in an infant who was symptomatic from neonatal age has hitherto not been reported in the literature