Open AccessChronic subdural hematoma-unsual cause of headache in a patient with chronic myeloid leukemia treated with high-dose imatinib mesylate: A rare case report with review of literature
Author(s) -
Sanjay M. Khaladkar,
Dhaval Thakkar,
Mansi Jantre,
Vilas M Kulkarni,
Amarjit Singh
Publication year - 2015
Publication title -
medical journal of dr. d y patil university/medical journal of dr. d.y. patil university
Language(s) - English
Resource type - Journals
eISSN - 2278-7119
pISSN - 0975-2870
DOI - 10.4103/0975-2870.157113
Subject(s) - medicine , imatinib mesylate , myeloid leukemia , hematoma , tolerability , surgery , chronic subdural hematoma , imatinib , gastroenterology , adverse effect
Head injury is considered one of the single most important causes of subdural hematoma. Other cause include bleeding diasthesis. We report here a case of 70-year-old female patient with chronic myeloid leukemia (CML) presenting with bilateral chronic subdural hematoma after an incremental high-dose of imatinib mesylate (IM) due to loss of complete molecular response. IM is useful to treat a wide range of diseases, including Philadelphia chromosome-positive CML, as it has high tolerability and low incidence of minor side effects. Hemorrhage is a rare complication of IM. IM is associated with reduced α2-plasmin inhibitor and platelet dysfunction. This case report emphasizes on the need to consider chronic subdural hematoma as atypical cause of headache in a patient of CML taking high-dose IM