Open AccessRecurrent metastatic mixed germ cell tumor of central nervous system with additional seminomatous component
Author(s) -
Shrijeet Chakraborti,
Hema Kini,
Santosh Rai,
Arun Kumar
Publication year - 2015
Publication title -
medical journal of dr. d y patil university/medical journal of dr. d.y. patil university
Language(s) - English
Resource type - Journals
eISSN - 2278-7119
pISSN - 0975-2870
DOI - 10.4103/0975-2870.150498
Subject(s) - yolk sac , medicine , metastasis , embryonal carcinoma , radiation therapy , germ cell tumors , central nervous system , chemotherapy , cisplatin , germ cell , pathology , oncology , biology , cancer , embryo , gene , biochemistry , cellular differentiation , microbiology and biotechnology
Mixed germ cell tumors (GCTs) are aggressive tumors owing to poor response to therapy, frequent recurrence and metastasis. We present here a case of 29-year-old male with recurrent metastatic mixed GCT in the left parietal lobe, with right testicular primary. Interestingly, the recurrent tumor exhibited a seminomatous component, in addition to yolk sac tumor and embryonal carcinoma. The patient was treated with surgery, cranial radiotherapy and cisplatin-based chemotherapy. The metastatic intracranial tumor recurred twice and the patient died 18 months after the first appearance of central nervous system metastasis