Open AccessKidney injury molecule-1: A urinary biomarker for contrast-induced acute kidney injury
Author(s) -
M Vijayasimha,
V. Vijaya Padma,
Saroj Kumar Das Mujumdar,
P V V Satyanarayana,
Ashok Yadav
Publication year - 2014
Publication title -
medical journal of dr. d y patil university/medical journal of dr. d.y. patil university
Language(s) - English
Resource type - Journals
eISSN - 2278-7119
pISSN - 0975-2870
DOI - 10.4103/0975-2870.128974
Subject(s) - acute kidney injury , creatinine , medicine , biomarker , urinary system , urology , kidney , kidney disease , contrast induced nephropathy , urine , basal (medicine) , nephropathy , endocrinology , chemistry , insulin , biochemistry , diabetes mellitus
Background: Urinary kidney injury molecule 1 (KIM-1) is an early biomarker for renal damage. A few studies have been published analyzing the potential use of urinary KIM-1 as a biomarker for acute kidney injury (AKI). However, no study has been done related to AKI associated with contrast administration. Aim: To search for new markers to identify AKI associated with contrast administration earlier than serum creatinine. Materials and Methods: We studied 100 consecutive patients with normal serum creatinine undergoing angiographic procedure. We assessed urine KIM-1, at 4, 8, and 24 hours after the angiographic procedure. Serum creatinine was measured at basal, 24, and 48 hours after the procedure. Results: There was a significant rise in urinary KIM-1 levels at 24 hours after the angiographic procedure. The presence of contrast induced nephropathy associated with AKI was 12%. Conclusion: The present study highlighted the importance of urinary KIM-1 in detecting AKI associated with contrast administration earlier than Serum creatinine