Clinical evaluation of 0.2% hyaluronic acid containing gel in the treatment of gingivitis

Background: Hyaluronic acid is an extracellular constitute of the connective tissue that acts as both a barrier to plaque bacteria and fulfils a variety of extracellular functions that are vital to the maintenance of healthy gingival tissue. Recently, 0.2% hyaluronic acid is introduced as an anti-inflammatory agent for topical application in the treatment of gingivitis. Aims: To evaluate the therapeutic efficacy of 0.2% hyaluronic acid containing gel as an adjunct to scaling. Materials and Methods: Fifty patients belonging to both gender and ages ranging 15-40 years diagnosed with plaque-induced gingivitis were included in the study. They were divided into two groups of 25 each; Group 1 (scaling and with 0.2% hyaluronic acid) and Group 2 (scaling alone). Plaque, gingival, and papillary bleeding index of each patient were recorded at baseline, 1, 2 and 4 week periods. Statistical analysis: Data was analyzed using Student′s t test. Results: Comparison of the two treatment modalities revealed a statistically significant improvement in the clinical parameters for both groups at 4 th week with mean reductions in Gingival Index (GI) was 1.13 ± 0.22 (Group 1) and 0.85 ± 0.17 (Group 2), respectively, which was statistically highly significant (P ≤ 0.001), Papillary Bleeding Index (PBI) was 1.22 ± 0.31 and 0.83 ± 0.24, respectively, which was statistically highly significant (P < 0.001). Conclusions : 0.2% hyaluronic acid containing gel is an effective agent for treating plaque-induced gingivitis as an adjunct to scaling as compared to scaling alone