Open AccessCombination of intracameral and intrastromal voriconazole in the treatment of recalcitrant Acremonium fungal keratitis
Author(s) -
Randa Haddad,
Georges M. El-Mollayess
Publication year - 2012
Publication title -
middle east african journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.357
H-Index - 25
eISSN - 0975-1599
pISSN - 0974-9233
DOI - 10.4103/0974-9233.95271
Subject(s) - voriconazole , medicine , fungal keratitis , natamycin , surgery , dermatology , keratitis , corneal disease , cornea , ophthalmology , pathology , antifungal
We present a report of a 28-year-old female with fungal keratitis due to Acremonium that was unresponsive to full medical therapy over 3 weeks. The patient was treated with superficial keratectomy, intrastromal and intracameral voriconazole injections. There was a marked clinical improvement beginning on day 3 post-therapy that was sustained until the last follow-up at 6 months. This is the first case of fungal keratitis due to Acremonium treated by a combination of intrastromal and intracameral voriconazole. This cost-effective treatment modality proved to be significant in impeding the progression of this potentially blinding disease and improving visual prognosis.