Combination of intracameral and intrastromal voriconazole in the treatment of recalcitrant Acremonium fungal keratitis | Zendy

RandaS Haddad | Zendy; GeorgesM El-Mollayess | Zendy

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Combination of intracameral and intrastromal voriconazole in the treatment of recalcitrant Acremonium fungal keratitis

Author(s) -

RandaS Haddad,

GeorgesM El-Mollayess

Publication year - 2012

Publication title -

middle east african journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.357

H-Index - 25

eISSN - 0975-1599

pISSN - 0974-9233

DOI - 10.4103/0974-9233.95271

Subject(s) - voriconazole , medicine , fungal keratitis , natamycin , surgery , dermatology , keratitis , corneal disease , cornea , ophthalmology , pathology , antifungal

We present a report of a 28-year-old female with fungal keratitis due to Acremonium that was unresponsive to full medical therapy over 3 weeks. The patient was treated with superficial keratectomy, intrastromal and intracameral voriconazole injections. There was a marked clinical improvement beginning on day 3 post-therapy that was sustained until the last follow-up at 6 months. This is the first case of fungal keratitis due to Acremonium treated by a combination of intrastromal and intracameral voriconazole. This cost-effective treatment modality proved to be significant in impeding the progression of this potentially blinding disease and improving visual prognosis.

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