Open AccessRole of inflammation in the pathogenesis of diabetic retinopathy
Author(s) -
Ahmed M. Abu ElAsrar
Publication year - 2012
Publication title -
middle east african journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.357
H-Index - 25
eISSN - 0975-1599
pISSN - 0974-9233
DOI - 10.4103/0974-9233.92118
Subject(s) - pathogenesis , medicine , polyol pathway , diabetic retinopathy , inflammation , glycation , oxidative stress , blindness , advanced glycation end product , diabetes mellitus , bioinformatics , immunology , endocrinology , biology , optometry , aldose reductase
Diabetic retinopathy (DR) remains a major cause of worldwide preventable blindness. The microvasculature of the retina responds to hyperglycemia through a number of biochemical changes, including activation of protein kinase C, increased advanced glycation end products formation, polyol pathway, and oxidative stress, and activation of the renin angiotensin system (RAS). There is an accumulating body of evidence that inflammation plays a prominent role in the pathogenesis of DR.