Open AccessPossible implication of oxidative stress in anti filarial effect of certain traditionally used medicinal plants in vitro against Brugia malayi microfilariae
Author(s) -
Ruchika Sharma,
AR Veerpathran,
Gajalakshmi Dakshinamoorthy,
KN Sahare,
Kalyan Goswami,
M. V. R. Reddy
Publication year - 2010
Publication title -
pharmacognosy research
Language(s) - English
Resource type - Journals
eISSN - 0976-4836
pISSN - 0974-8490
DOI - 10.4103/0974-8490.75453
Subject(s) - ricinus , traditional medicine , oxidative stress , lipid peroxidation , polyphenol , medicinal plants , biology , antioxidant , botany , chemistry , pharmacology , biochemistry , medicine
Tropical disease research scheme of World Health Organization has duly recognized traditional medicine as alternative for antifilarial drug development. Polyphenolic compounds present in traditionally used herbal medicines are natural antioxidants; however, paradoxically they may exert pro-oxidant effect. Popular drug diethyl carbamazine citrate harnesses the innate inflammatory response and the consequent oxidative assault to combat invading microbes.