Open AccessDetermination of cutoff of ELISA and immunofluorescence assay for scrub typhus
Author(s) -
Nitin Gupta,
Rama Chaudhry,
Chandan Kumar Thakur
Publication year - 2016
Publication title -
journal of global infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 25
eISSN - 0974-8245
pISSN - 0974-777X
DOI - 10.4103/0974-777x.188584
Subject(s) - scrub typhus , eschar , receiver operating characteristic , medicine , cutoff , titer , antibody , serial dilution , orientia tsutsugamushi , serology , indirect immunofluorescence , immunology , virology , pathology , physics , alternative medicine , quantum mechanics
The most common method employed for diagnosis of scrub typhus is serology. It is widely known that demonstration of ≥4-fold rise in titers of antibody in paired sera is required for diagnosis. However, for guidance of initial treatment, there is a need for rapid diagnosis at the time of admission. Therefore, there is a need for standardized region specific cutoff titers at the time of admission.