Open AccessDisseminated bacillus calmette guerin disease in a twin infant with severe combined immunodeficiency disease
Author(s) -
H. M. Mittal,
M. M. A. Faridi,
Pankaj Kumar,
Anju Aggarwal
Publication year - 2014
Publication title -
journal of global infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 25
eISSN - 0974-8245
pISSN - 0974-777X
DOI - 10.4103/0974-777x.138514
Subject(s) - mycobacterium bovis , immunodeficiency , disease , medicine , severe combined immunodeficiency , immunology , vaccination , polymerase chain reaction , bacillus (shape) , dermatology , pathology , biology , tuberculosis , microbiology and biotechnology , immune system , mycobacterium tuberculosis , in vivo , biochemistry , gene
Fatal-disseminated Bacillus Calmette Guerin (BCG) disease is well known in infants with severe combined immunodeficiency after BCG vaccination. We report a 7 month male infant delivered as a product of in vitro fertilization and twin gestation that presented with fever, cough and multiple nodular skin lesions. A biopsy of skin lesions revealed the presence of acid fast bacilli. Mycobacterium bovis infection was confirmed by polymerase chain reaction (PCR) and molecular studies. Immunological profile confirmed the diagnosis of severe combined immunodeficiency. Only few reports of similar case exist in the literature.