Open AccessThe Plasmodium falciparum Antigen MB2 Induces Interferon-γ and Interleukin-10 Responses in Adults in Malaria Endemic Areas of Western Kenya
Author(s) -
Lyticia Ochola,
Gideon Ngwena,
Gregory S. Noland,
Bartholomew N. Ondigo,
George Ayodo,
Chandy C. John
Publication year - 2013
Publication title -
journal of global infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 25
eISSN - 0974-8245
pISSN - 0974-777X
DOI - 10.4103/0974-777x.122001
Subject(s) - elispot , plasmodium falciparum , malaria , immunology , antigen , immune system , biology , human leukocyte antigen , interferon gamma , virology , t cell
MB2 is a novel Plasmodium falciparum antigen of unknown function expressed in pre-erythrocytic and blood stages of infection in the human host. Interferon-gamma (IFN-γ) and interleukin (IL)-10 responses to other P. falciparum antigens have been associated with protection from clinical malaria, but these responses have not been studied for MB2. The present study was undertaken to characterize IFN-γ and IL-10 responses to P. falciparum MB2 antigen in adults living in areas of differing malaria transmission in Western Kenya.