Open AccessSilvery grey hair: Clue to diagnose immunodeficiency
Author(s) -
Sahana,
S Sacchidanand,
Ravi Hiremagalore,
GS Asha
Publication year - 2012
Publication title -
international journal of trichology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 22
eISSN - 0974-9241
pISSN - 0974-7753
DOI - 10.4103/0974-7753.96910
Subject(s) - hair shaft , dermatology , biology , chédiak–higashi syndrome , immunodeficiency , melanosome , albinism , pathology , medicine , immunology , genetics , hair follicle , melanin , microbiology and biotechnology , immune system
Silvery hair is a common presentation of rare group of autosomal recessive disorders called Silvery hair syndromes including Griscelli syndrome (GS), Chediak-Higashi syndrome, and Elejalde syndrome. GS is characterized by a silvery grey sheen to hair, large clumped melanosomes in hair shaft, partial albinism, and variable cellular immunodeficiency. We report two cases of GS with classical clinical features and confirmatory findings by microscopic skin and hair examination.