Open AccessThe effect of ovine secreted soluble factors on human dermal papilla cell aggregation
Author(s) -
Agnes Rosarina Prita Sari,
Nicholas W Rufaut,
L Jones,
Rodney Sinclair
Publication year - 2016
Publication title -
international journal of trichology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.494
H-Index - 22
eISSN - 0974-9241
pISSN - 0974-7753
DOI - 10.4103/0974-7753.188963
Subject(s) - dermal papillae , hair follicle , transplantation , in vitro , secretion , cell culture , biology , microbiology and biotechnology , chemistry , andrology , endocrinology , medicine , biochemistry , genetics
In androgenetic alopecia, follicular miniaturization and dynamic changes to the hair cycle produce patterned baldness. The most effective treatment for baldness is hair transplantation surgery. The major limitation to hair transplantation is the availability of donor hair from the relatively unaffected occipital scalp. Hair induction with in vitro expansion of donor follicle populations has the potential to overcome this. The major obstacle to this is that in vitro expansion of human dermal papilla cell (DPC) colonies is associated with irreversible loss of aggregative behavior and hair follicle-inductive potential. In contrast, cultured ovine DPCs maintain these properties after extensive proliferation.