Open AccessCytological diagnosis of solitary plasmacytoma of the skull: A rare case report
Author(s) -
Mohamad Banyameen Iqbal,
Iqra Mushtaq,
Tushar Kambale,
Atul Jain
Publication year - 2015
Publication title -
journal of the scientific society
Language(s) - English
Resource type - Journals
eISSN - 2278-7127
pISSN - 0974-5009
DOI - 10.4103/0974-5009.149486
Subject(s) - medicine , bence jones protein , plasmacytoma , multiple myeloma , skull , pathology , bone marrow , bone marrow examination , immunoglobulin light chain , biopsy , radiology , antibody , anatomy , immunology
Solitary plasmacytoma (SPC) of the skull (SPS) is rare, and only a few cases have been reported in the literature so far. Plasmacytoma of the skull has a wide spectrum of pathology, including a quite benign, SPC, and an extremely malignant, multiple myeloma at the two ends of the spectrum. SPC of bone including SPS is characterized by a radiologically solitary bone lesion, neoplastic plasma cells in the biopsy specimen, fewer than 5% plasma cells in bone marrow, <2.0 g/dl monoclonal protein in the serum when present and negative urine test for Bence Jones protein (monoclonal light chain). For diagnosing, a comprehensive examination and analysis, which includes radiological examination, immunoglobulin, biochemistry, test for Bence Jones protein in the urine and bone marrow is needed