Open AccessCeliac disease manifesting as isolated cobalamin deficiency megaloblastic anemia: Case series and review
Author(s) -
Vikram Kumar,
Suresh Birur Parmeshwarappa,
Arunkumar Ragulapadu Vadde
Publication year - 2014
Publication title -
journal of the scientific society
Language(s) - English
Resource type - Journals
eISSN - 2278-7127
pISSN - 0974-5009
DOI - 10.4103/0974-5009.141246
Subject(s) - enteropathy , medicine , megaloblastic anemia , cobalamin , disease , gluten , anemia , immune system , immunology , diarrhea , gastroenterology , pathology , vitamin b12
Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. It has been identified as one of the most common lifelong disorders on a worldwide basis. Enteropathy in CD is thought to be the final consequence of an abnormal immune reaction, showing features of both an innate and adaptive response to gluten prolamins. The clinical spectrum is wide, including cases with either typical intestinal or atypical extra intestinal features, or silent forms. Anemia has frequently been reported as the only manifestation or the most frequent extra-intestinal symptom of CD. The only available treatment consists in dietary exclusion of grains containing gluten