Open AccessSynthesis and evaluation of anti-tubercular activity of some novel 2-pyrazoline derivatives
Author(s) -
S. M. Hipparagi,
M. D. Bhanushali
Publication year - 2013
Publication title -
journal of the scientific society
Language(s) - English
Resource type - Journals
eISSN - 2278-7127
pISSN - 0974-5009
DOI - 10.4103/0974-5009.115475
Subject(s) - pyrazoline , benzaldehyde , acrylamide , combinatorial chemistry , spectral analysis , aryl , nuclear chemistry , medicine , stereochemistry , chemistry , organic chemistry , spectroscopy , polymer , physics , alkyl , quantum mechanics , copolymer , catalysis
Purpose: Pyrazolines and its derivatives are reported to possess a wide spectrum of biological activities. Many class of chemotherapeutic agents containing pyrazoline nucleus are in clinical use. The purpose of this present study was to examine whether the molecular modification might result in detection of new potent anti-tubercular agent. Materials and Methods: A series of 2-pyrazoline compounds (P13-P24) have synthesized by treating N-(substituted aryl)-acrylamide (C13-C24). The starting material was synthesized from substituted P-aminoacetophenone and substituted benzaldehyde. Their structure was confirmed by infrared and 1 H NMR spectral data. The synthesized compounds were screened for anti-tubercular activity by Microplate Alamar Blue Assay method. Results: Compound P 15 and P 20 have shown excellent anti-tubercular activity; compound P 16 and P 22 have shown significant activity as compared with the standard and rest of them have shown moderate to low anti-tubercular activity. Conclusion: These compounds may result in the potent anti-tubercular entity with molecular modification and manipulations