Open AccessRole of p16/INK4a and Ki-67 as specific biomarkers for cervical intraepithelial neoplasia: An institutional study
Author(s) -
Ankitha Hebbar,
V Srinivasa Murthy
Publication year - 2017
Publication title -
journal of laboratory physicians
Language(s) - English
Resource type - Journals
eISSN - 0974-7826
pISSN - 0974-2727
DOI - 10.4103/0974-2727.199630
Subject(s) - histopathology , medicine , cervical intraepithelial neoplasia , ki 67 , biopsy , pathology , concordance , gold standard (test) , squamous metaplasia , dysplasia , intraepithelial neoplasia , cytology , koilocyte , cervical cancer , immunohistochemistry , cancer , prostate , epithelium
P16/INK4a and Ki-67 have emerged as important biomarkers for the detection of high-risk human papilloma virus (HR-HPV) associated dysplastic changes in the cervical biopsy samples. The increasing inter- and intra-observer variability in the diagnosis of dysplastic lesions and immature squamous metaplasia on histopathology has led to the advent of these biomarkers. This study was taken up with an aim to study their role in increasing the diagnostic accuracy in equivocal cases on histopathology.