Open AccessImmunohistochemistry-based comparative study in detection of Hirschsprung’s disease in infants in a Tertiary Care Center
Author(s) -
Bedabrata Mukhopadhyay,
Moumita Sengupta,
Chhanda Das,
Madhumita Mukhopadhyay,
Shibsankar Barman,
Biswanath Mukhopadhyay
Publication year - 2017
Publication title -
journal of laboratory physicians
Language(s) - English
Resource type - Journals
eISSN - 0974-7826
pISSN - 0974-2727
DOI - 10.4103/0974-2727.199623
Subject(s) - tertiary care , hirschsprung's disease , center (category theory) , immunohistochemistry , medicine , disease , pediatrics , pathology , chemistry , crystallography
Hirschsprung's disease (HD) is the major cause of pediatric intestinal obstruction with a complex pattern of inheritance. The absence of ganglion cells along with an analysis of hypertrophy and hyperplasia of nerves in the nerve plexus of submucosa and muscularis mucosae is regarded as a potential hallmark for its diagnosis.